Annie & Ivern
Arena is all about two-on-two fights, but Annie and Ivern can make it more like a four-on-two by using their ultimates to summon Tibbers and Daisy. Annie and Ivern can make the fight even more wild by bringing their two pets with them. Both pets can block oncoming skill shots and draw attention away from themselves.
Annie and Ivern also work well together in other ways. As helpful champions, they can shield each other to keep each other living, for example. Ivern’s Q can help get Annie close enough to use her short-range magic to stun.
Kalista & Darius
Darius will always do a lot of damage to anyone he can get on top of because he is a monster. But without dashes, it’s hard for him to do that. Both of these super-strong early-game champions can steamroll from the start, since Kalista can ult him into the enemy and knock them down.
Kalista also doesn’t fall off as often as she does in normal League. Teamfights have always been one of her problems, but she doesn’t have to do them in Breakout Game.
Singed & Cassiopeia
Many players know that Cassiopeia’s E, Twin Fang, does more damage to poisoned targets and heals them at the same time. They also know that this works on enemies who have been poisoned by champions besides Cassio. Cassiopeia is usually a midlaner, though, and not many champions have poison damage, so this exchange is rarely used.
In the new 2v2v2v2 mode, Cassiopeia can team up with Singed to poison enemies to death while their grounding skills keep them from moving. This is one of many Arena teams that players will hate playing against.
Mordekaiser & Kha’Zix
Mordekaiser and Kha’Zix make an interesting team, but they are only good when fighting two enemies at the same time in the Arena. The idea behind this mix is easy to understand. If an enemy is alone, Kha’Zix’s Q does more damage to them. Also, if Mordekaiser uses his ultimate ability to send one of the enemies to the death realm, Kha’Zix will be left to kill the lone prey.
The person controlling Mordekaiser should try to ult the enemy who has more health, and they don’t even have to fight. It doesn’t matter what the Morde does as long as he buys time for his buddy.
Shaco & Neeko
Shaco and Neeko are probably the two best tricksters in League. Arena is the best place for them to cause chaos and throw off their opponents so much that they lose. There can be four Shacos at once, thanks to Shaco’s ultimate clone and Neeko’s power to take on Shaco’s appearance and even make her own clone.
Neeko won’t be able to turn into minions because she doesn’t have any, but she will be able to turn into Blast Cones and the new Power Flower plants. Some of Arena’s strangest Augments, which are similar to the Augments in Teamfight Tactics, can also help this team’s tricks hit new heights.
Master Yi & Taric
Master Yi and Taric have always been a strong duo in League of Legends, but since Yi is a jungler and Taric is a support, they don’t get to play together much outside of funnel tactics that have been nerfed over the years. In Arena, though, they can stick together and do what they do best.
Yi and Taric work so well together because, once they are tied together with Taric’s W. Master Yi can go as deep as he wants, knowing that help is always close by. One of the best parts of this combo is that Yi can be stunned by Taric’. Since Yi doesn’t have any CC to make up for his high damage potential. In a fighting game mode, Taric’s ultimate, which makes them both invincible, is strong. Especially since Master Yi’s Alpha Strike makes him impossible to hit.
Heimerdinger & Zyra
Heimerdinger and Zyra are one of the best champion teams for Arena, and it’s easy to see why. With Heimerdinger’s turrets and Zyra’s plants. Enemies who want to attack the two mages will lose most of their power before they even reach them.
Normal League doesn’t force the enemy to fight. But in Arena, if Heimerdinger and Zyra just set up shop in the middle of the map. The ring of fire will finally come to them and the enemy won’t be able to do anything about it. They both have a lot of crowd control moves that can be chained together and great damage per second to get through Arena’s bigger health bars.